| Date | Home | Away | Result |
|---|---|---|---|
| 1/21/22 1:45 PM | KV Oostende | Royal Antwerp FC | 1-2 |
| 1/22/22 9:15 AM | KV Kortrijk | KAS Eupen | 1-1 |
| 1/22/22 11:30 AM | Sint-Truidense VV | RFC Seraing | 3-1 |
| 1/22/22 11:30 AM | K. Beerschot V.A. | OH Leuven | 3-1 |
| 1/22/22 1:45 PM | Sporting Charleroi | KAA Gent | 0-0 |
| 1/23/22 6:30 AM | Standard Liège | Club Brugge | 2-2 |
| 1/23/22 9:00 AM | Royale Union Saint-Gilloise | KRC Genk | 2-1 |
| 1/23/22 11:30 AM | KV Mechelen | RSC Anderlecht | 0-1 |
| 1/23/22 2:00 PM | KSV Cercle Brügge | SV Zulte-Waregem | 3-1 |