| Date | Home | Away | Result |
|---|---|---|---|
| 2/4/22 1:45 PM | Sporting Charleroi | RFC Seraing | 2-0 |
| 2/5/22 9:15 AM | KV Kortrijk | Sint-Truidense VV | 1-3 |
| 2/5/22 11:30 AM | Standard Liège | KSV Cercle Brügge | 1-1 |
| 2/5/22 11:30 AM | KV Oostende | OH Leuven | 1-3 |
| 2/5/22 1:45 PM | Royal Antwerp FC | Royale Union Saint-Gilloise | 0-2 |
| 2/6/22 6:30 AM | Club Brugge | KAA Gent | 1-2 |
| 2/6/22 9:00 AM | KV Mechelen | K. Beerschot V.A. | 3-2 |
| 2/6/22 11:30 AM | RSC Anderlecht | KAS Eupen | 4-1 |
| 2/6/22 2:00 PM | KRC Genk | SV Zulte-Waregem | 2-0 |