| Date | Home | Away | Result |
|---|---|---|---|
| 2/11/22 1:45 PM | RFC Seraing | Royal Antwerp FC | 0-1 |
| 2/12/22 9:15 AM | KAS Eupen | KAA Gent | 0-1 |
| 2/12/22 11:30 AM | KV Mechelen | KV Oostende | 3-0 |
| 2/12/22 11:30 AM | OH Leuven | KSV Cercle Brügge | 3-2 |
| 2/12/22 1:45 PM | SV Zulte-Waregem | RSC Anderlecht | 1-2 |
| 2/13/22 6:30 AM | KRC Genk | Standard Liège | 2-0 |
| 2/13/22 9:00 AM | Royale Union Saint-Gilloise | Sint-Truidense VV | 0-1 |
| 2/13/22 11:30 AM | Club Brugge | Sporting Charleroi | 2-0 |
| 2/13/22 2:00 PM | K. Beerschot V.A. | KV Kortrijk | 2-1 |