| Date | Home | Away | Result |
|---|---|---|---|
| 8/6/21 1:45 PM | Club Brugge | KSV Cercle Brügge | 1-1 |
| 8/7/21 9:15 AM | K. Beerschot V.A. | Royale Union Saint-Gilloise | 0-3 |
| 8/7/21 11:30 AM | Sint-Truidense VV | SV Zulte-Waregem | 1-3 |
| 8/7/21 11:30 AM | KV Mechelen | KAS Eupen | 1-3 |
| 8/7/21 1:45 PM | KV Kortrijk | KRC Genk | 1-2 |
| 8/8/21 6:30 AM | Standard Liège | Royal Antwerp FC | 2-5 |
| 8/8/21 9:00 AM | OH Leuven | Sporting Charleroi | 1-1 |
| 8/8/21 11:30 AM | RSC Anderlecht | RFC Seraing | 3-0 |
| 8/8/21 2:00 PM | KV Oostende | KAA Gent | 1-0 |