| Date | Home | Away | Result |
|---|---|---|---|
| 3/11/22 1:45 PM | OH Leuven | Royale Union Saint-Gilloise | 1-4 |
| 3/12/22 9:15 AM | KV Mechelen | Sporting Charleroi | 2-2 |
| 3/12/22 11:30 AM | KSV Cercle Brügge | KV Kortrijk | 2-0 |
| 3/12/22 11:30 AM | SV Zulte-Waregem | KAS Eupen | 3-0 |
| 3/12/22 1:45 PM | KV Oostende | Club Brugge | 1-3 |
| 3/13/22 7:30 AM | RSC Anderlecht | Royal Antwerp FC | 2-1 |
| 3/13/22 10:00 AM | KRC Genk | Sint-Truidense VV | 0-1 |
| 3/13/22 12:30 PM | K. Beerschot V.A. | KAA Gent | 0-2 |
| 3/13/22 3:00 PM | Standard Liège | RFC Seraing | 0-1 |