| Date | Home | Away | Result |
|---|---|---|---|
| 3/18/22 2:45 PM | Royale Union Saint-Gilloise | KV Oostende | 1-1 |
| 3/19/22 10:15 AM | KAS Eupen | KV Mechelen | 1-1 |
| 3/19/22 12:30 PM | RFC Seraing | OH Leuven | 1-1 |
| 3/19/22 12:30 PM | Sporting Charleroi | KSV Cercle Brügge | 5-0 |
| 3/19/22 2:45 PM | Royal Antwerp FC | SV Zulte-Waregem | 1-0 |
| 3/20/22 7:30 AM | Club Brugge | KRC Genk | 3-1 |
| 3/20/22 10:00 AM | KV Kortrijk | Standard Liège | 0-1 |
| 3/20/22 12:30 PM | KAA Gent | RSC Anderlecht | 1-0 |
| 3/20/22 3:00 PM | Sint-Truidense VV | K. Beerschot V.A. | 3-2 |