| Date | Home | Away | Result |
|---|---|---|---|
| 12/10/21 1:45 PM | Sporting Charleroi | KV Oostende | 1-0 |
| 12/11/21 9:15 AM | KV Kortrijk | OH Leuven | 2-1 |
| 12/11/21 11:30 AM | Sint-Truidense VV | KSV Cercle Brügge | 1-2 |
| 12/11/21 11:30 AM | KAS Eupen | K. Beerschot V.A. | 1-0 |
| 12/11/21 1:45 PM | RFC Seraing | RSC Anderlecht | 0-5 |
| 12/12/21 6:30 AM | Royal Antwerp FC | Standard Liège | 2-3 |
| 12/12/21 9:00 AM | Royale Union Saint-Gilloise | KV Mechelen | 2-0 |
| 12/12/21 11:30 AM | KAA Gent | KRC Genk | 1-0 |
| 12/12/21 2:00 PM | Club Brugge | SV Zulte-Waregem | 3-0 |