| Date | Home | Away | Result |
|---|---|---|---|
| 8/20/21 1:45 PM | Standard Liège | KV Oostende | 1-0 |
| 8/21/21 9:15 AM | RFC Seraing | KSV Cercle Brügge | 2-1 |
| 8/21/21 11:30 AM | OH Leuven | KAS Eupen | 1-4 |
| 8/21/21 1:45 PM | Sint-Truidense VV | KV Kortrijk | 0-2 |
| 8/22/21 9:00 AM | SV Zulte-Waregem | Sporting Charleroi | 2-2 |
| 8/22/21 11:30 AM | Club Brugge | K. Beerschot V.A. | 3-2 |
| 8/22/21 2:00 PM | KV Mechelen | Royale Union Saint-Gilloise | 3-1 |
| 9/22/21 1:45 PM | Royal Antwerp FC | KRC Genk | 4-2 |
| 9/23/21 1:45 PM | RSC Anderlecht | KAA Gent | 1-1 |