| Date | Home | Away | Result |
|---|---|---|---|
| 7/23/21 1:45 PM | Standard Liège | KRC Genk | 1-1 |
| 7/24/21 9:15 AM | OH Leuven | SV Zulte-Waregem | 1-1 |
| 7/24/21 11:30 AM | KV Kortrijk | RFC Seraing | 2-0 |
| 7/24/21 1:45 PM | KV Oostende | Sporting Charleroi | 0-3 |
| 7/25/21 6:30 AM | KV Mechelen | Royal Antwerp FC | 3-2 |
| 7/25/21 9:00 AM | Club Brugge | KAS Eupen | 2-2 |
| 7/25/21 11:30 AM | RSC Anderlecht | Royale Union Saint-Gilloise | 1-3 |
| 7/25/21 2:00 PM | Sint-Truidense VV | KAA Gent | 2-1 |
| 7/27/21 1:00 PM | K. Beerschot V.A. | KSV Cercle Brügge | 0-1 |