| Date | Home | Away | Result |
|---|---|---|---|
| 10/22/21 1:45 PM | RFC Seraing | Sporting Charleroi | 1-3 |
| 10/23/21 9:15 AM | KSV Cercle Brügge | Standard Liège | 1-1 |
| 10/23/21 11:30 AM | KV Kortrijk | KV Oostende | 1-0 |
| 10/23/21 11:30 AM | KV Mechelen | SV Zulte-Waregem | 2-2 |
| 10/23/21 1:45 PM | KAS Eupen | Royale Union Saint-Gilloise | 2-3 |
| 10/24/21 6:30 AM | Royal Antwerp FC | Club Brugge | 1-1 |
| 10/24/21 9:00 AM | RSC Anderlecht | K. Beerschot V.A. | 4-2 |
| 10/24/21 11:30 AM | KRC Genk | KAA Gent | 0-3 |
| 10/24/21 2:00 PM | OH Leuven | Sint-Truidense VV | 4-1 |