| Date | Home | Away | Result |
|---|---|---|---|
| 11/19/21 1:45 PM | KV Mechelen | Club Brugge | 2-1 |
| 11/20/21 9:15 AM | KSV Cercle Brügge | Sporting Charleroi | 1-2 |
| 11/20/21 11:30 AM | OH Leuven | RFC Seraing | 1-3 |
| 11/20/21 11:30 AM | SV Zulte-Waregem | KAA Gent | 1-2 |
| 11/20/21 1:45 PM | Standard Liège | KAS Eupen | 1-0 |
| 11/21/21 6:30 AM | RSC Anderlecht | KV Kortrijk | 1-1 |
| 11/21/21 9:00 AM | Sint-Truidense VV | Royal Antwerp FC | 2-1 |
| 11/21/21 11:30 AM | KV Oostende | Royale Union Saint-Gilloise | 1-7 |
| 11/21/21 2:00 PM | K. Beerschot V.A. | KRC Genk | 2-0 |