| Date | Home | Away | Result |
|---|---|---|---|
| 11/26/21 1:45 PM | Royale Union Saint-Gilloise | OH Leuven | 1-3 |
| 11/27/21 9:15 AM | RFC Seraing | Sint-Truidense VV | 2-0 |
| 11/27/21 11:30 AM | KSV Cercle Brügge | KV Mechelen | 3-1 |
| 11/27/21 11:30 AM | KAS Eupen | KV Kortrijk | 2-2 |
| 11/27/21 1:45 PM | Sporting Charleroi | RSC Anderlecht | 1-3 |
| 11/28/21 6:30 AM | KRC Genk | Club Brugge | 2-3 |
| 11/28/21 9:00 AM | SV Zulte-Waregem | K. Beerschot V.A. | 2-0 |
| 11/28/21 11:30 AM | KAA Gent | Standard Liège | 3-1 |
| 11/28/21 2:00 PM | Royal Antwerp FC | KV Oostende | 3-0 |