| Date | Home | Away | Result |
|---|---|---|---|
| 7/30/21 1:45 PM | KRC Genk | KV Oostende | 3-4 |
| 7/31/21 9:15 AM | Sporting Charleroi | Sint-Truidense VV | 0-0 |
| 7/31/21 11:30 AM | KSV Cercle Brügge | OH Leuven | 1-1 |
| 7/31/21 11:30 AM | RFC Seraing | KV Mechelen | 1-0 |
| 7/31/21 1:45 PM | KAS Eupen | RSC Anderlecht | 1-1 |
| 8/1/21 6:30 AM | Royale Union Saint-Gilloise | Club Brugge | 0-1 |
| 8/1/21 9:00 AM | SV Zulte-Waregem | Standard Liège | 1-2 |
| 8/1/21 11:30 AM | KAA Gent | K. Beerschot V.A. | 2-2 |
| 8/1/21 2:00 PM | Royal Antwerp FC | KV Kortrijk | 0-1 |