| Date | Home | Away | Result |
|---|---|---|---|
| 1/14/22 1:45 PM | KAA Gent | KV Kortrijk | 2-2 |
| 1/15/22 9:15 AM | OH Leuven | KV Mechelen | 5-0 |
| 1/15/22 1:45 PM | Club Brugge | Sint-Truidense VV | 2-0 |
| 1/16/22 6:30 AM | Royal Antwerp FC | Sporting Charleroi | 3-0 |
| 1/16/22 9:00 AM | KAS Eupen | KSV Cercle Brügge | 0-2 |
| 1/16/22 11:30 AM | RSC Anderlecht | Standard Liège | 1-1 |
| 1/16/22 2:00 PM | KRC Genk | K. Beerschot V.A. | 4-1 |
| 1/18/22 1:00 PM | RFC Seraing | Royale Union Saint-Gilloise | 0-4 |
| 2/9/22 11:45 AM | SV Zulte-Waregem | KV Oostende | 0-0 |