| Date | Home | Away | Result |
|---|---|---|---|
| 1/25/22 11:45 AM | Royal Antwerp FC | Sint-Truidense VV | 1-1 |
| 1/25/22 2:00 PM | Sporting Charleroi | KV Kortrijk | 1-1 |
| 1/25/22 2:00 PM | KAA Gent | KV Oostende | 1-1 |
| 1/26/22 11:45 AM | KAS Eupen | Standard Liège | 0-2 |
| 1/26/22 11:45 AM | SV Zulte-Waregem | OH Leuven | 1-1 |
| 1/26/22 2:00 PM | RFC Seraing | K. Beerschot V.A. | 2-1 |
| 1/26/22 2:00 PM | RSC Anderlecht | KSV Cercle Brügge | 0-2 |
| 1/27/22 1:45 PM | Club Brugge | Royale Union Saint-Gilloise | 0-0 |
| 2/16/22 11:45 AM | KRC Genk | KV Mechelen | 4-1 |