| Date | Home | Away | Result |
|---|---|---|---|
| 1/28/22 1:45 PM | Sint-Truidense VV | Sporting Charleroi | 0-1 |
| 1/29/22 9:15 AM | K. Beerschot V.A. | SV Zulte-Waregem | 3-3 |
| 1/29/22 11:30 AM | RFC Seraing | KAS Eupen | 0-0 |
| 1/29/22 1:45 PM | KSV Cercle Brügge | KV Oostende | 0-1 |
| 1/30/22 6:30 AM | Royale Union Saint-Gilloise | RSC Anderlecht | 1-0 |
| 1/30/22 9:00 AM | KAA Gent | Royal Antwerp FC | 0-1 |
| 1/30/22 11:30 AM | Standard Liège | KV Mechelen | 1-2 |
| 1/30/22 2:00 PM | KV Kortrijk | Club Brugge | 0-1 |
| 2/9/22 2:00 PM | OH Leuven | KRC Genk | 2-1 |