| Date | Home | Away | Result |
|---|---|---|---|
| 2/19/22 9:15 AM | KSV Cercle Brügge | K. Beerschot V.A. | 2-0 |
| 2/19/22 11:30 AM | KV Kortrijk | SV Zulte-Waregem | 5-0 |
| 2/19/22 11:30 AM | KV Oostende | Standard Liège | 1-0 |
| 2/19/22 1:45 PM | Sporting Charleroi | Royale Union Saint-Gilloise | 0-3 |
| 2/20/22 6:30 AM | Royal Antwerp FC | KV Mechelen | 1-2 |
| 2/20/22 9:00 AM | KAS Eupen | Club Brugge | 1-3 |
| 2/20/22 11:30 AM | RSC Anderlecht | KRC Genk | 2-0 |
| 2/20/22 2:00 PM | Sint-Truidense VV | OH Leuven | 2-0 |
| 2/23/22 11:45 AM | KAA Gent | RFC Seraing | 4-0 |