| Date | Home | Away | Result |
|---|---|---|---|
| 2/25/22 1:45 PM | K. Beerschot V.A. | Sporting Charleroi | 2-3 |
| 2/26/22 9:15 AM | Royale Union Saint-Gilloise | KAS Eupen | 0-0 |
| 2/26/22 11:30 AM | KV Mechelen | KSV Cercle Brügge | 2-2 |
| 2/26/22 11:30 AM | KV Oostende | Sint-Truidense VV | 0-0 |
| 2/26/22 1:45 PM | OH Leuven | RSC Anderlecht | 0-0 |
| 2/27/22 6:30 AM | Club Brugge | Royal Antwerp FC | 4-1 |
| 2/27/22 9:00 AM | KRC Genk | KV Kortrijk | 2-0 |
| 2/27/22 11:30 AM | Standard Liège | KAA Gent | 0-1 |
| 2/27/22 2:00 PM | SV Zulte-Waregem | RFC Seraing | 1-0 |