| Date | Home | Away | Result |
|---|---|---|---|
| 3/4/22 1:45 PM | Sint-Truidense VV | KV Mechelen | 1-1 |
| 3/5/22 9:15 AM | KSV Cercle Brügge | KRC Genk | 2-2 |
| 3/5/22 11:30 AM | KV Kortrijk | Royale Union Saint-Gilloise | 2-3 |
| 3/5/22 1:45 PM | RFC Seraing | Club Brugge | 0-5 |
| 3/6/22 6:30 AM | Royal Antwerp FC | K. Beerschot V.A. | 2-1 |
| 3/6/22 9:00 AM | RSC Anderlecht | KV Oostende | 3-0 |
| 3/6/22 11:30 AM | Sporting Charleroi | Standard Liège | 0-0 |
| 3/6/22 2:00 PM | KAS Eupen | OH Leuven | 3-1 |
| 3/6/22 2:00 PM | KAA Gent | SV Zulte-Waregem | 2-1 |