| Date | Home | Away | Result |
|---|---|---|---|
| 4/1/22 1:45 PM | K. Beerschot V.A. | Club Brugge | 1-3 |
| 4/2/22 9:15 AM | SV Zulte-Waregem | Sint-Truidense VV | 0-2 |
| 4/2/22 11:30 AM | KV Mechelen | KV Kortrijk | 3-2 |
| 4/2/22 11:30 AM | KV Oostende | RFC Seraing | 2-2 |
| 4/2/22 1:45 PM | OH Leuven | Royal Antwerp FC | 0-1 |
| 4/3/22 6:30 AM | Standard Liège | Royale Union Saint-Gilloise | 1-3 |
| 4/3/22 9:00 AM | KSV Cercle Brügge | KAA Gent | 2-2 |
| 4/3/22 11:30 AM | RSC Anderlecht | Sporting Charleroi | 4-0 |
| 4/3/22 2:00 PM | KRC Genk | KAS Eupen | 5-0 |