| Date | Home | Away | Result |
|---|---|---|---|
| 4/9/22 11:30 AM | KAS Eupen | KV Oostende | 0-2 |
| 4/9/22 1:45 PM | Royal Antwerp FC | KSV Cercle Brügge | 1-1 |
| 4/10/22 11:30 AM | Sint-Truidense VV | Standard Liège | 3-0 |
| 4/10/22 11:30 AM | Sporting Charleroi | SV Zulte-Waregem | 3-0 |
| 4/10/22 11:30 AM | Club Brugge | KV Mechelen | 2-0 |
| 4/10/22 11:30 AM | KAA Gent | OH Leuven | 5-0 |
| 4/10/22 11:30 AM | RFC Seraing | KRC Genk | 0-2 |
| 4/10/22 11:30 AM | Royale Union Saint-Gilloise | K. Beerschot V.A. | 5-0 |
| 4/10/22 11:30 AM | KV Kortrijk | RSC Anderlecht | 2-3 |