| Date | Home | Away | Result |
|---|---|---|---|
| 8/27/21 1:45 PM | KV Kortrijk | KV Mechelen | 2-2 |
| 8/28/21 9:15 AM | Sporting Charleroi | K. Beerschot V.A. | 5-2 |
| 8/28/21 11:30 AM | KAS Eupen | RFC Seraing | 1-2 |
| 8/28/21 11:30 AM | KSV Cercle Brügge | Sint-Truidense VV | 0-1 |
| 8/28/21 1:45 PM | Royale Union Saint-Gilloise | Standard Liège | 4-0 |
| 8/29/21 6:30 AM | KAA Gent | Club Brugge | 6-1 |
| 8/29/21 9:00 AM | Royal Antwerp FC | OH Leuven | 2-2 |
| 8/29/21 11:30 AM | KRC Genk | RSC Anderlecht | 1-0 |
| 8/29/21 2:00 PM | KV Oostende | SV Zulte-Waregem | 0-2 |