| Date | Home | Away | Result |
|---|---|---|---|
| 9/24/21 1:45 PM | Club Brugge | OH Leuven | 1-1 |
| 9/25/21 9:15 AM | K. Beerschot V.A. | KAS Eupen | 0-3 |
| 9/25/21 11:30 AM | SV Zulte-Waregem | KV Kortrijk | 2-2 |
| 9/25/21 1:45 PM | Standard Liège | Sint-Truidense VV | 1-2 |
| 9/26/21 6:30 AM | Royale Union Saint-Gilloise | Royal Antwerp FC | 1-2 |
| 9/26/21 9:00 AM | KAA Gent | KSV Cercle Brügge | 2-1 |
| 9/26/21 11:30 AM | KV Oostende | RSC Anderlecht | 2-2 |
| 9/26/21 2:00 PM | KRC Genk | RFC Seraing | 3-0 |
| 9/26/21 2:00 PM | Sporting Charleroi | KV Mechelen | 0-2 |