Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 3/5/22 8:00 AM | 3/5/22 8:00 AM | Castres Olympique | Montpellier Hérault RC | 25-9 | 3 - 10 - 7 |
| 3/5/22 10:00 AM | 3/5/22 10:00 AM | Atlantique Stade Rochelais | CA Brive | 41-15 | 3 - 10 - 10 |
| 3/5/22 10:00 AM | 3/5/22 10:00 AM | Union Bordeaux Bègles | Section Paloise | 16-23 | 3 - 10 - 10 |
| 3/5/22 10:00 AM | 3/5/22 10:00 AM | Biarritz | RC Toulon | 17-45 | 5 - 10 - 4 |
| 3/5/22 10:00 AM | 3/5/22 10:00 AM | USA Perpignan | Racing Métro 92 | 34-13 | 9 - 10 - 3 |
| 3/5/22 2:05 PM | 3/5/22 2:05 PM | ASM Clermont Auvergne | Lyon OU | 25-16 | 3 - 10 - 8 |
| 3/6/22 2:05 PM | 3/6/22 2:05 PM | Stade Français | Stade Toulousain | 23-16 | 4 - 10 - 5 |