Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 9/18/21 8:00 AM | 9/18/21 8:00 AM | CA Brive | Section Paloise | 30-13 | 3 - 10 - 9 |
| 9/18/21 8:00 AM | 9/18/21 8:00 AM | Lyon OU | USA Perpignan | 47-3 | 3 - 10 - 10 |
| 9/18/21 8:00 AM | 9/18/21 8:00 AM | Biarritz | Racing Métro 92 | 28-19 | 7 - 10 - 3 |
| 9/18/21 8:00 AM | 9/18/21 8:00 AM | Castres Olympique | Union Bordeaux Bègles | 23-23 | 3 - 10 - 6 |
| 9/18/21 10:00 AM | 9/18/21 10:00 AM | Montpellier Hérault RC | Stade Toulousain | 15-17 | 6 - 10 - 3 |
| 9/18/21 2:05 PM | 9/18/21 2:05 PM | ASM Clermont Auvergne | Atlantique Stade Rochelais | 23-22 | 3 - 10 - 5 |
| 9/19/21 2:10 PM | 9/19/21 2:10 PM | RC Toulon | Stade Français | 38-5 | 3 - 10 - 7 |