Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 10/9/21 8:00 AM | 10/9/21 8:00 AM | Atlantique Stade Rochelais | Castres Olympique | 29-10 | 3 - 10 - 10 |
| 10/9/21 8:00 AM | 10/9/21 8:00 AM | Union Bordeaux Bègles | Montpellier Hérault RC | 27-23 | 3 - 10 - 10 |
| 10/9/21 8:00 AM | 10/9/21 8:00 AM | Racing Métro 92 | USA Perpignan | 17-14 | 3 - 10 - 10 |
| 10/9/21 8:00 AM | 10/9/21 8:00 AM | Biarritz | Lyon OU | 5-40 | 4 - 10 - 4 |
| 10/9/21 10:00 AM | 10/9/21 10:00 AM | Stade Toulousain | Section Paloise | 38-10 | 3 - 10 - 10 |
| 10/9/21 2:05 PM | 10/9/21 2:05 PM | RC Toulon | CA Brive | 13-9 | 3 - 10 - 10 |
| 10/10/21 2:10 PM | 10/10/21 2:10 PM | Stade Français | ASM Clermont Auvergne | 22-14 | 5 - 10 - 4 |