Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 10/16/21 8:00 AM | 10/16/21 8:00 AM | Section Paloise | Union Bordeaux Bègles | 33-37 | 4 - 10 - 4 |
| 10/16/21 8:00 AM | 10/16/21 8:00 AM | CA Brive | Atlantique Stade Rochelais | 6-8 | 4 - 10 - 4 |
| 10/16/21 8:00 AM | 10/16/21 8:00 AM | Castres Olympique | Biarritz | 38-20 | 3 - 10 - 10 |
| 10/16/21 8:00 AM | 10/16/21 8:00 AM | USA Perpignan | Stade Français | 22-23 | 3 - 10 - 5 |
| 10/16/21 10:00 AM | 10/16/21 10:00 AM | Montpellier Hérault RC | ASM Clermont Auvergne | 20-22 | 3 - 10 - 6 |
| 10/16/21 2:05 PM | 10/16/21 2:05 PM | RC Toulon | Racing Métro 92 | 20-27 | 4 - 10 - 5 |
| 10/17/21 2:05 PM | 10/17/21 2:05 PM | Lyon OU | Stade Toulousain | 25-19 | 5 - 10 - 4 |