Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 10/19/21 12:00 PM | 10/19/21 12:00 PM | FC Cartagena | Sporting Gijon | 1-0 | 5 - 7 points |
| 10/19/21 12:00 PM | 10/19/21 12:00 PM | SD Huesca | FC Malaga | 0-0 | 5 - 7 points |
| 10/19/21 2:00 PM | 10/19/21 2:00 PM | CD Teneriffa | SD Eibar | 0-1 | 5 - 7 points |
| 10/20/21 12:00 PM | 10/20/21 12:00 PM | Real Valladolid | UD Ibiza Eivissa | 1-1 | 5 - 7 points |
| 10/20/21 12:00 PM | 10/20/21 12:00 PM | CF Fuenlabrada | SD Amorebieta | 0-0 | 5 - 7 points |
| 10/20/21 2:00 PM | 10/20/21 2:00 PM | AD Alcorcon | CD Leganes | 3-3 | 5 - 7 points |
| 10/20/21 2:00 PM | 10/20/21 2:00 PM | CD Lugo | UD Las Palmas | 2-0 | 5 - 7 points |
| 10/21/21 11:45 AM | 10/21/21 11:45 AM | UD Almeria | Real Sociedad B | 3-1 | 5 - 7 points |
| 10/21/21 12:00 PM | 10/21/21 12:00 PM | Real Saragossa | SD Ponferradina | 1-1 | 5 - 7 points |
| 10/21/21 2:00 PM | 10/21/21 2:00 PM | CD Mirandes | FC Girona | 1-2 | 5 - 7 points |
| 10/21/21 2:00 PM | 10/21/21 2:00 PM | Real Oviedo | Burgos CF | 1-3 | 5 - 7 points |