Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 11/2/21 1:00 PM | 11/2/21 1:00 PM | SD Ponferradina | SD Huesca | 1-1 | 5 - 7 points |
| 11/2/21 1:00 PM | 11/2/21 1:00 PM | Sporting Gijon | UD Almeria | 0-1 | 5 - 7 points |
| 11/2/21 3:15 PM | 11/2/21 3:15 PM | CD Leganes | FC Cartagena | 1-1 | 5 - 7 points |
| 11/3/21 1:00 PM | 11/3/21 1:00 PM | CD Mirandes | CD Lugo | 3-2 | 5 - 7 points |
| 11/3/21 1:00 PM | 11/3/21 1:00 PM | SD Amorebieta | Real Valladolid | 4-1 | 5 - 7 points |
| 11/3/21 3:15 PM | 11/3/21 3:15 PM | SD Eibar | Real Oviedo | 1-0 | 5 - 7 points |
| 11/3/21 3:15 PM | 11/3/21 3:15 PM | UD Las Palmas | CF Fuenlabrada | 2-1 | 5 - 7 points |
| 11/4/21 1:00 PM | 11/4/21 1:00 PM | Burgos CF | Real Saragossa | 0-1 | 5 - 7 points |
| 11/4/21 1:00 PM | 11/4/21 1:00 PM | FC Girona | AD Alcorcon | 3-1 | 5 - 7 points |
| 11/4/21 3:15 PM | 11/4/21 3:15 PM | FC Malaga | Real Sociedad B | 2-1 | 5 - 7 points |
| 11/4/21 3:15 PM | 11/4/21 3:15 PM | UD Ibiza Eivissa | CD Teneriffa | 0-0 | 5 - 7 points |