Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 11/19/21 2:00 PM | 11/19/21 2:00 PM | CF Fuenlabrada | CD Mirandes | 1-1 | 5 - 7 points |
| 11/20/21 9:00 AM | 11/20/21 9:00 AM | Real Oviedo | SD Amorebieta | 2-0 | 5 - 7 points |
| 11/20/21 11:15 AM | 11/20/21 11:15 AM | FC Malaga | UD Las Palmas | 2-1 | 5 - 7 points |
| 11/20/21 1:30 PM | 11/20/21 1:30 PM | UD Almeria | Real Valladolid | 3-1 | 5 - 7 points |
| 11/21/21 7:00 AM | 11/21/21 7:00 AM | FC Cartagena | Burgos CF | 1-0 | 5 - 7 points |
| 11/21/21 9:00 AM | 11/21/21 9:00 AM | CD Lugo | SD Eibar | 2-2 | 5 - 7 points |
| 11/21/21 11:15 AM | 11/21/21 11:15 AM | CD Teneriffa | AD Alcorcon | 1-0 | 5 - 7 points |
| 11/21/21 11:15 AM | 11/21/21 11:15 AM | SD Huesca | UD Ibiza Eivissa | 0-0 | 5 - 7 points |
| 11/21/21 1:30 PM | 11/21/21 1:30 PM | SD Ponferradina | Sporting Gijon | 4-1 | 5 - 7 points |
| 11/22/21 12:00 PM | 11/22/21 12:00 PM | Real Sociedad B | FC Girona | 1-2 | 5 - 7 points |
| 11/22/21 2:00 PM | 11/22/21 2:00 PM | Real Saragossa | CD Leganes | 0-2 | 5 - 7 points |