Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 9/10/21 2:00 PM | 9/10/21 2:00 PM | Sporting Gijon | CD Leganes | 2-1 | 5 - 7 points |
| 9/11/21 9:00 AM | 9/11/21 9:00 AM | SD Amorebieta | Burgos CF | 2-2 | 5 - 7 points |
| 9/11/21 9:00 AM | 9/11/21 9:00 AM | Real Sociedad B | SD Eibar | 2-3 | 5 - 7 points |
| 9/11/21 11:15 AM | 9/11/21 11:15 AM | UD Las Palmas | UD Ibiza Eivissa | 1-1 | 5 - 7 points |
| 9/11/21 2:00 PM | 9/11/21 2:00 PM | CD Mirandes | AD Alcorcon | 1-3 | 5 - 7 points |
| 9/12/21 7:00 AM | 9/12/21 7:00 AM | Real Oviedo | FC Cartagena | 2-0 | 5 - 7 points |
| 9/12/21 9:00 AM | 9/12/21 9:00 AM | Real Valladolid | CD Teneriffa | 0-2 | 5 - 7 points |
| 9/12/21 11:15 AM | 9/12/21 11:15 AM | SD Ponferradina | UD Almeria | 1-0 | 5 - 7 points |
| 9/12/21 1:30 PM | 9/12/21 1:30 PM | CF Fuenlabrada | Real Saragossa | 1-1 | 5 - 7 points |
| 9/12/21 2:30 PM | 9/12/21 2:30 PM | FC Malaga | FC Girona | 2-0 | 5 - 7 points |
| 9/13/21 2:00 PM | 9/13/21 2:00 PM | CD Lugo | SD Huesca | 3-2 | 5 - 7 points |