Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 9/17/21 2:00 PM | 9/17/21 2:00 PM | AD Alcorcon | UD Almeria | 0-4 | 5 - 7 points |
| 9/18/21 9:00 AM | 9/18/21 9:00 AM | UD Ibiza Eivissa | Real Oviedo | 1-1 | 5 - 7 points |
| 9/18/21 11:15 AM | 9/18/21 11:15 AM | Real Saragossa | Real Sociedad B | 1-1 | 5 - 7 points |
| 9/18/21 11:15 AM | 9/18/21 11:15 AM | CD Leganes | SD Amorebieta | 1-0 | 5 - 7 points |
| 9/18/21 1:30 PM | 9/18/21 1:30 PM | FC Girona | Real Valladolid | 1-0 | 5 - 7 points |
| 9/18/21 2:00 PM | 9/18/21 2:00 PM | FC Cartagena | CD Lugo | 2-1 | 5 - 7 points |
| 9/19/21 7:00 AM | 9/19/21 7:00 AM | SD Huesca | CF Fuenlabrada | 0-0 | 5 - 7 points |
| 9/19/21 9:00 AM | 9/19/21 9:00 AM | SD Ponferradina | FC Malaga | 4-0 | 5 - 7 points |
| 9/19/21 11:15 AM | 9/19/21 11:15 AM | SD Eibar | Sporting Gijon | 3-2 | 5 - 7 points |
| 9/19/21 11:15 AM | 9/19/21 11:15 AM | CD Teneriffa | CD Mirandes | 1-2 | 5 - 7 points |
| 9/20/21 2:00 PM | 9/20/21 2:00 PM | Burgos CF | UD Las Palmas | 0-0 | 5 - 7 points |