Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 10/1/21 2:00 PM | 10/1/21 2:00 PM | SD Ponferradina | Real Valladolid | 2-2 | 5 - 7 points |
| 10/2/21 9:00 AM | 10/2/21 9:00 AM | SD Amorebieta | Sporting Gijon | 1-1 | 5 - 7 points |
| 10/2/21 9:00 AM | 10/2/21 9:00 AM | SD Huesca | CD Teneriffa | 1-2 | 5 - 7 points |
| 10/2/21 11:15 AM | 10/2/21 11:15 AM | Real Saragossa | Real Oviedo | 0-0 | 5 - 7 points |
| 10/2/21 2:00 PM | 10/2/21 2:00 PM | AD Alcorcon | Real Sociedad B | 1-4 | 5 - 7 points |
| 10/3/21 7:00 AM | 10/3/21 7:00 AM | SD Eibar | UD Ibiza Eivissa | 3-1 | 5 - 7 points |
| 10/3/21 9:00 AM | 10/3/21 9:00 AM | FC Malaga | CF Fuenlabrada | 1-0 | 5 - 7 points |
| 10/3/21 11:15 AM | 10/3/21 11:15 AM | Burgos CF | CD Mirandes | 1-0 | 5 - 7 points |
| 10/3/21 11:15 AM | 10/3/21 11:15 AM | UD Las Palmas | FC Cartagena | 4-1 | 5 - 7 points |
| 10/3/21 2:00 PM | 10/3/21 2:00 PM | CD Leganes | CD Lugo | 1-1 | 5 - 7 points |
| 10/4/21 2:00 PM | 10/4/21 2:00 PM | FC Girona | UD Almeria | 1-2 | 5 - 7 points |