Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 10/29/21 11:30 AM | 10/29/21 11:30 AM | SV Darmstadt 98 | 1. FC Nürnberg | 2-0 | 5 - 7 points |
| 10/29/21 11:30 AM | 10/29/21 11:30 AM | 1. FC Heidenheim 1846 | FC Schalke 04 | 1-0 | 5 - 7 points |
| 10/30/21 6:30 AM | 10/30/21 6:30 AM | Werder Bremen | FC St. Pauli | 1-1 | 5 - 7 points |
| 10/30/21 6:30 AM | 10/30/21 6:30 AM | Hannover 96 | Erzgebirge Aue | 1-1 | 5 - 7 points |
| 10/30/21 6:30 AM | 10/30/21 6:30 AM | Dynamo Dresden | SV Sandhausen | 0-1 | 5 - 7 points |
| 10/30/21 1:30 PM | 10/30/21 1:30 PM | Hamburger SV | Holstein Kiel | 1-1 | 5 - 7 points |
| 10/31/21 7:30 AM | 10/31/21 7:30 AM | Karlsruher SC | SC Paderborn 07 | 2-4 | 5 - 7 points |
| 10/31/21 7:30 AM | 10/31/21 7:30 AM | FC Hansa Rostock | Fortuna Düsseldorf | 2-1 | 5 - 7 points |
| 10/31/21 7:30 AM | 10/31/21 7:30 AM | FC Ingolstadt | Jahn Regensburg | 0-3 | 5 - 7 points |