| Date | Home | Away | Group | Result |
|---|---|---|---|---|
| 10/4/22 11:45 AM | FC Bayern Munich | Viktoria Plzen | Group C | 5-0 |
| 10/4/22 12:05 PM | Olympique Marseille | Sporting Lisbon | Group D | 4-1 |
| 10/4/22 2:00 PM | Liverpool FC | Glasgow Rangers | Group A | 2-0 |
| 10/4/22 2:00 PM | Ajax Amsterdam | SSC Napoli | Group A | 1-6 |
| 10/4/22 2:00 PM | Club Brugge | Atletico Madrid | Group B | 2-0 |
| 10/4/22 2:00 PM | FC Porto | Bayer 04 Leverkusen | Group B | 2-0 |
| 10/4/22 2:00 PM | Inter Milan | FC Barcelona | Group C | 1-0 |
| 10/4/22 2:00 PM | Eintracht Frankfurt | Tottenham Hotspur | Group D | 0-0 |
| 10/5/22 11:45 AM | RB Leipzig | Celtic Glasgow | Group F | 3-1 |
| 10/5/22 11:45 AM | FC Red Bull Salzburg | Dinamo Zagreb | Group E | 1-0 |
| 10/5/22 2:00 PM | Real Madrid | Schachtjor Donezk | Group F | 2-1 |
| 10/5/22 2:00 PM | FC Sevilla | Borussia Dortmund | Group G | 1-4 |
| 10/5/22 2:00 PM | Manchester City | FC Copenhagen | Group G | 5-0 |
| 10/5/22 2:00 PM | Juventus Turin | Maccabi Haifa | Group H | 3-1 |
| 10/5/22 2:00 PM | Benfica Lisbon | Paris St. Germain | Group H | 1-1 |
| 10/5/22 2:00 PM | Chelsea FC | AC Milan | Group E | 3-0 |