| Date | Home | Away | Group | Result |
|---|---|---|---|---|
| 11/1/22 12:45 PM | FC Porto | Atletico Madrid | Group B | 2-1 |
| 11/1/22 12:45 PM | Bayer 04 Leverkusen | Club Brugge | Group B | 0-0 |
| 11/1/22 3:00 PM | Liverpool FC | SSC Napoli | Group A | 2-0 |
| 11/1/22 3:00 PM | Glasgow Rangers | Ajax Amsterdam | Group A | 1-3 |
| 11/1/22 3:00 PM | Viktoria Plzen | FC Barcelona | Group C | 2-4 |
| 11/1/22 3:00 PM | FC Bayern Munich | Inter Milan | Group C | 2-0 |
| 11/1/22 3:00 PM | Olympique Marseille | Tottenham Hotspur | Group D | 1-2 |
| 11/1/22 3:00 PM | Sporting Lisbon | Eintracht Frankfurt | Group D | 1-2 |
| 11/2/22 12:45 PM | Real Madrid | Celtic Glasgow | Group F | 5-1 |
| 11/2/22 12:45 PM | Schachtjor Donezk | RB Leipzig | Group F | 0-4 |
| 11/2/22 3:00 PM | Manchester City | FC Sevilla | Group G | 3-1 |
| 11/2/22 3:00 PM | FC Copenhagen | Borussia Dortmund | Group G | 1-1 |
| 11/2/22 3:00 PM | Maccabi Haifa | Benfica Lisbon | Group H | 1-6 |
| 11/2/22 3:00 PM | Chelsea FC | Dinamo Zagreb | Group E | 2-1 |
| 11/2/22 3:00 PM | Juventus Turin | Paris St. Germain | Group H | 1-2 |
| 11/2/22 3:00 PM | AC Milan | FC Red Bull Salzburg | Group E | 4-0 |