| Date | Home | Away | Group | Result |
|---|---|---|---|---|
| 9/15/22 11:45 AM | Real Sociedad | Omonia Nicosia | Group E | 2-1 |
| 9/15/22 11:45 AM | AS Monaco | Ferencvaros Budapest | Group H | 0-1 |
| 9/15/22 11:45 AM | Trabzonspor | Red Star Belgrad | Group H | 2-1 |
| 9/15/22 11:45 AM | Feyenoord Rotterdam | SK Sturm Graz | Group F | 6-0 |
| 9/15/22 11:45 AM | FC Midtjylland | Lazio Rom | Group F | 5-1 |
| 9/15/22 11:45 AM | Olympiakos Piräus | SC Freiburg | Group G | 0-3 |
| 9/15/22 11:45 AM | Qarabag | FC Nantes | Group G | 3-0 |
| 9/15/22 11:45 AM | Sheriff Tiraspol | Manchester United | Group E | 0-2 |
| 9/15/22 2:00 PM | Real Betis Sevilla | PFC Ludogorets Razgrad | Group C | 3-2 |
| 9/15/22 2:00 PM | AS Roma | HJK Helsinki | Group C | 3-0 |
| 9/15/22 2:00 PM | Stade Rennes | Fenerbahce Istanbul | Group B | 2-2 |
| 9/15/22 2:00 PM | Dynamo Kiew | AEK Larnaka | Group B | 0-1 |
| 9/15/22 2:00 PM | FK Bodö/Glimt | FC Zürich | Group A | 2-1 |
| 9/15/22 2:00 PM | Sporting Braga | 1. FC Union Berlin | Group D | 1-0 |
| 9/15/22 2:00 PM | Royale Union Saint-Gilloise | Malmö FF | Group D | 3-2 |
| 10/20/22 12:00 PM | Arsenal FC | PSV Eindhoven | Group A | 1-0 |