| Date | Home | Away | Group | Result |
|---|---|---|---|---|
| 11/3/22 12:45 PM | Sheriff Tiraspol | Omonia Nicosia | Group E | 1-0 |
| 11/3/22 12:45 PM | Real Sociedad | Manchester United | Group E | 0-1 |
| 11/3/22 12:45 PM | Trabzonspor | Ferencvaros Budapest | Group H | 1-0 |
| 11/3/22 12:45 PM | AS Monaco | Red Star Belgrad | Group H | 4-1 |
| 11/3/22 12:45 PM | Feyenoord Rotterdam | Lazio Rom | Group F | 1-0 |
| 11/3/22 12:45 PM | FC Midtjylland | SK Sturm Graz | Group F | 2-0 |
| 11/3/22 12:45 PM | Olympiakos Piräus | FC Nantes | Group G | 0-2 |
| 11/3/22 12:45 PM | Qarabag | SC Freiburg | Group G | 1-1 |
| 11/3/22 3:00 PM | FK Bodö/Glimt | PSV Eindhoven | Group A | 1-2 |
| 11/3/22 3:00 PM | Royale Union Saint-Gilloise | 1. FC Union Berlin | Group D | 0-1 |
| 11/3/22 3:00 PM | Sporting Braga | Malmö FF | Group D | 2-1 |
| 11/3/22 3:00 PM | AS Roma | PFC Ludogorets Razgrad | Group C | 3-1 |
| 11/3/22 3:00 PM | Real Betis Sevilla | HJK Helsinki | Group C | 3-0 |
| 11/3/22 3:00 PM | Dynamo Kiew | Fenerbahce Istanbul | Group B | 0-2 |
| 11/3/22 3:00 PM | Stade Rennes | AEK Larnaka | Group B | 1-1 |
| 11/3/22 3:00 PM | Arsenal FC | FC Zürich | Group A | 1-0 |