Schedule
| Date | Dead line | Home | Away | Group | Result | Points rule |
|---|---|---|---|---|---|---|
| 9/15/21 9:30 AM | 9/15/21 9:30 AM | Spartak Moscow | Legia Warschau | Group C | 0-1 | 5 - 7 points |
| 9/16/21 11:45 AM | 9/16/21 11:45 AM | SK Rapid Wien | KRC Genk | Group H | 0-1 | 5 - 7 points |
| 9/16/21 11:45 AM | 9/16/21 11:45 AM | Bayer 04 Leverkusen | Ferencvaros Budapest | Group G | 2-1 | 5 - 7 points |
| 9/16/21 11:45 AM | 9/16/21 11:45 AM | Real Betis Sevilla | Celtic Glasgow | Group G | 4-3 | 5 - 7 points |
| 9/16/21 11:45 AM | 9/16/21 11:45 AM | Galatasaray Istanbul | Lazio Rom | Group E | 1-0 | 5 - 7 points |
| 9/16/21 11:45 AM | 9/16/21 11:45 AM | Lokomotive Moscow | Olympique Marseille | Group E | 1-1 | 5 - 7 points |
| 9/16/21 11:45 AM | 9/16/21 11:45 AM | FC Midtjylland | PFC Ludogorets Razgrad | Group F | 1-1 | 5 - 7 points |
| 9/16/21 11:45 AM | 9/16/21 11:45 AM | Red Star Belgrad | Sporting Braga | Group F | 2-1 | 5 - 7 points |
| 9/16/21 11:45 AM | 9/16/21 11:45 AM | Dinamo Zagreb | West Ham United | Group H | 0-2 | 5 - 7 points |
| 9/16/21 2:00 PM | 9/16/21 2:00 PM | AS Monaco | SK Sturm Graz | Group B | 1-0 | 5 - 7 points |
| 9/16/21 2:00 PM | 9/16/21 2:00 PM | PSV Eindhoven | Real Sociedad | Group B | 2-2 | 5 - 7 points |
| 9/16/21 2:00 PM | 9/16/21 2:00 PM | Eintracht Frankfurt | Fenerbahce Istanbul | Group D | 1-1 | 5 - 7 points |
| 9/16/21 2:00 PM | 9/16/21 2:00 PM | Olympiakos Piräus | Royal Antwerp FC | Group D | 2-1 | 5 - 7 points |
| 9/16/21 2:00 PM | 9/16/21 2:00 PM | Glasgow Rangers | Olympique Lyon | Group A | 0-2 | 5 - 7 points |
| 9/16/21 2:00 PM | 9/16/21 2:00 PM | Bröndby IF Copenhagen | Sparta Prag | Group A | 0-0 | 5 - 7 points |
| 9/16/21 2:00 PM | 9/16/21 2:00 PM | Leicester City | SSC Napoli | Group C | 2-2 | 5 - 7 points |