Schedule
| Date | Dead line | Home | Away | Group | Result | Points rule |
|---|---|---|---|---|---|---|
| 9/30/21 11:45 AM | 9/30/21 11:45 AM | Real Sociedad | AS Monaco | Group B | 1-1 | 5 - 7 points |
| 9/30/21 11:45 AM | 9/30/21 11:45 AM | SK Sturm Graz | PSV Eindhoven | Group B | 1-4 | 5 - 7 points |
| 9/30/21 11:45 AM | 9/30/21 11:45 AM | Fenerbahce Istanbul | Olympiakos Piräus | Group D | 0-3 | 5 - 7 points |
| 9/30/21 11:45 AM | 9/30/21 11:45 AM | Royal Antwerp FC | Eintracht Frankfurt | Group D | 0-1 | 5 - 7 points |
| 9/30/21 11:45 AM | 9/30/21 11:45 AM | Sparta Prag | Glasgow Rangers | Group A | 1-0 | 5 - 7 points |
| 9/30/21 11:45 AM | 9/30/21 11:45 AM | Olympique Lyon | Bröndby IF Copenhagen | Group A | 3-0 | 5 - 7 points |
| 9/30/21 11:45 AM | 9/30/21 11:45 AM | Legia Warschau | Leicester City | Group C | 1-0 | 5 - 7 points |
| 9/30/21 11:45 AM | 9/30/21 11:45 AM | SSC Napoli | Spartak Moscow | Group C | 2-3 | 5 - 7 points |
| 9/30/21 2:00 PM | 9/30/21 2:00 PM | KRC Genk | Dinamo Zagreb | Group H | 0-3 | 5 - 7 points |
| 9/30/21 2:00 PM | 9/30/21 2:00 PM | West Ham United | SK Rapid Wien | Group H | 2-0 | 5 - 7 points |
| 9/30/21 2:00 PM | 9/30/21 2:00 PM | Ferencvaros Budapest | Real Betis Sevilla | Group G | 1-3 | 5 - 7 points |
| 9/30/21 2:00 PM | 9/30/21 2:00 PM | Celtic Glasgow | Bayer 04 Leverkusen | Group G | 0-4 | 5 - 7 points |
| 9/30/21 2:00 PM | 9/30/21 2:00 PM | Lazio Rom | Lokomotive Moscow | Group E | 2-0 | 5 - 7 points |
| 9/30/21 2:00 PM | 9/30/21 2:00 PM | Olympique Marseille | Galatasaray Istanbul | Group E | 0-0 | 5 - 7 points |
| 9/30/21 2:00 PM | 9/30/21 2:00 PM | PFC Ludogorets Razgrad | Red Star Belgrad | Group F | 0-1 | 5 - 7 points |
| 9/30/21 2:00 PM | 9/30/21 2:00 PM | Sporting Braga | FC Midtjylland | Group F | 3-1 | 5 - 7 points |