Schedule
| Date | Dead line | Home | Away | Group | Result | Points rule |
|---|---|---|---|---|---|---|
| 10/19/21 9:30 AM | 10/19/21 9:30 AM | Celtic Glasgow | Ferencvaros Budapest | Group G | 2-0 | 5 - 7 points |
| 10/20/21 9:30 AM | 10/20/21 9:30 AM | Spartak Moscow | Leicester City | Group C | 3-4 | 5 - 7 points |
| 10/21/21 11:45 AM | 10/21/21 11:45 AM | SK Rapid Wien | Dinamo Zagreb | Group H | 2-1 | 5 - 7 points |
| 10/21/21 11:45 AM | 10/21/21 11:45 AM | Real Betis Sevilla | Bayer 04 Leverkusen | Group G | 1-1 | 5 - 7 points |
| 10/21/21 11:45 AM | 10/21/21 11:45 AM | Lazio Rom | Olympique Marseille | Group E | 0-0 | 5 - 7 points |
| 10/21/21 11:45 AM | 10/21/21 11:45 AM | FC Midtjylland | Red Star Belgrad | Group F | 1-1 | 5 - 7 points |
| 10/21/21 11:45 AM | 10/21/21 11:45 AM | PFC Ludogorets Razgrad | Sporting Braga | Group F | 0-1 | 5 - 7 points |
| 10/21/21 11:45 AM | 10/21/21 11:45 AM | Fenerbahce Istanbul | Royal Antwerp FC | Group D | 2-2 | 5 - 7 points |
| 10/21/21 2:00 PM | 10/21/21 2:00 PM | SSC Napoli | Legia Warschau | Group C | 3-0 | 5 - 7 points |
| 10/21/21 2:00 PM | 10/21/21 2:00 PM | West Ham United | KRC Genk | Group H | 3-0 | 5 - 7 points |
| 10/21/21 2:00 PM | 10/21/21 2:00 PM | Lokomotive Moscow | Galatasaray Istanbul | Group E | 0-1 | 5 - 7 points |
| 10/21/21 2:00 PM | 10/21/21 2:00 PM | PSV Eindhoven | AS Monaco | Group B | 1-2 | 5 - 7 points |
| 10/21/21 2:00 PM | 10/21/21 2:00 PM | SK Sturm Graz | Real Sociedad | Group B | 0-1 | 5 - 7 points |
| 10/21/21 2:00 PM | 10/21/21 2:00 PM | Eintracht Frankfurt | Olympiakos Piräus | Group D | 3-1 | 5 - 7 points |
| 10/21/21 2:00 PM | 10/21/21 2:00 PM | Glasgow Rangers | Bröndby IF Copenhagen | Group A | 2-0 | 5 - 7 points |
| 10/21/21 2:00 PM | 10/21/21 2:00 PM | Sparta Prag | Olympique Lyon | Group A | 3-4 | 5 - 7 points |