Schedule
| Date | Dead line | Home | Away | Group | Result | Points rule |
|---|---|---|---|---|---|---|
| 12/9/21 11:45 AM | 12/9/21 11:45 AM | SSC Napoli | Leicester City | Group C | 3-2 | 5 - 7 points |
| 12/9/21 11:45 AM | 12/9/21 11:45 AM | Legia Warschau | Spartak Moscow | Group C | 0-1 | 5 - 7 points |
| 12/9/21 11:45 AM | 12/9/21 11:45 AM | Real Sociedad | PSV Eindhoven | Group B | 3-0 | 5 - 7 points |
| 12/9/21 11:45 AM | 12/9/21 11:45 AM | SK Sturm Graz | AS Monaco | Group B | 1-1 | 5 - 7 points |
| 12/9/21 11:45 AM | 12/9/21 11:45 AM | Fenerbahce Istanbul | Eintracht Frankfurt | Group D | 1-1 | 5 - 7 points |
| 12/9/21 11:45 AM | 12/9/21 11:45 AM | Royal Antwerp FC | Olympiakos Piräus | Group D | 1-0 | 5 - 7 points |
| 12/9/21 11:45 AM | 12/9/21 11:45 AM | Sparta Prag | Bröndby IF Copenhagen | Group A | 2-0 | 5 - 7 points |
| 12/9/21 11:45 AM | 12/9/21 11:45 AM | Olympique Lyon | Glasgow Rangers | Group A | 1-1 | 5 - 7 points |
| 12/9/21 2:00 PM | 12/9/21 2:00 PM | West Ham United | Dinamo Zagreb | Group H | 0-1 | 5 - 7 points |
| 12/9/21 2:00 PM | 12/9/21 2:00 PM | KRC Genk | SK Rapid Wien | Group H | 0-1 | 5 - 7 points |
| 12/9/21 2:00 PM | 12/9/21 2:00 PM | Ferencvaros Budapest | Bayer 04 Leverkusen | Group G | 1-0 | 5 - 7 points |
| 12/9/21 2:00 PM | 12/9/21 2:00 PM | Celtic Glasgow | Real Betis Sevilla | Group G | 3-2 | 5 - 7 points |
| 12/9/21 2:00 PM | 12/9/21 2:00 PM | Lazio Rom | Galatasaray Istanbul | Group E | 0-0 | 5 - 7 points |
| 12/9/21 2:00 PM | 12/9/21 2:00 PM | Olympique Marseille | Lokomotive Moscow | Group E | 1-0 | 5 - 7 points |
| 12/9/21 2:00 PM | 12/9/21 2:00 PM | Sporting Braga | Red Star Belgrad | Group F | 1-1 | 5 - 7 points |
| 12/9/21 2:00 PM | 12/9/21 2:00 PM | PFC Ludogorets Razgrad | FC Midtjylland | Group F | 0-0 | 5 - 7 points |