| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 5/14/22 1:30 PM | 5/14/22 1:30 PM | VfB Stuttgart | 1. FC Köln | 2-1 | 2 - 4 points |
| 5/14/22 1:30 PM | 5/14/22 1:30 PM | Bor. Mönchengladbach | 1899 Hoffenheim | 5-1 | 2 - 4 points |
| 5/14/22 1:30 PM | 5/14/22 1:30 PM | 1. FC Union Berlin | VfL Bochum | 3-2 | 2 - 4 points |
| 5/14/22 1:30 PM | 5/14/22 1:30 PM | Bayer 04 Leverkusen | SC Freiburg | 2-1 | 2 - 4 points |
| 5/14/22 1:30 PM | 5/14/22 1:30 PM | Borussia Dortmund | Hertha BSC | 2-1 | 2 - 4 points |
| 5/14/22 1:30 PM | 5/14/22 1:30 PM | Arminia Bielefeld | RB Leipzig | 1-1 | 2 - 4 points |
| 5/14/22 1:30 PM | 5/14/22 1:30 PM | FC Augsburg | SpVgg Greuther Fürth | 2-1 | 2 - 4 points |
| 5/14/22 1:30 PM | 5/14/22 1:30 PM | FSV Mainz 05 | Eintracht Frankfurt | 2-2 | 2 - 4 points |
| 5/14/22 1:35 PM | 5/14/22 1:35 PM | VfL Wolfsburg | FC Bayern Munich | 2-2 | 2 - 4 points |