| Date | Home | Away | Result |
|---|---|---|---|
| 10/4/22 1:45 PM | Luton Town | Huddersfield Town | 3-3 |
| 10/4/22 1:45 PM | Bristol City | Coventry City | 0-0 |
| 10/4/22 1:45 PM | Sheffield United | Queens Park Rangers | 0-1 |
| 10/4/22 1:45 PM | AFC Sunderland | FC Blackpool | 0-0 |
| 10/4/22 2:00 PM | Cardiff City | Blackburn Rovers | 1-0 |
| 10/4/22 2:00 PM | Reading FC | Norwich City | 1-1 |
| 10/5/22 1:45 PM | Hull City A.F.C. | Wigan Athletic | 2-1 |
| 10/5/22 1:45 PM | Rotherham United | Millwall FC | 1-1 |
| 10/5/22 1:45 PM | Middlesbrough FC | Birmingham City | 1-0 |
| 10/5/22 1:45 PM | Burnley FC | Stoke City | 1-1 |
| 10/5/22 1:45 PM | Watford FC | Swansea City | 1-2 |
| 10/5/22 2:00 PM | Preston North End | West Bromwich Albion | 1-0 |