Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 8/13/21 1:00 PM | 8/13/21 1:00 PM | Go Ahead Eagles Deventer | SC Heerenveen | 0-1 | 2 - 4 points |
| 8/14/21 9:30 AM | 8/14/21 9:30 AM | RKC Waalwijk | AZ Alkmaar | 1-0 | 2 - 4 points |
| 8/14/21 11:45 AM | 8/14/21 11:45 AM | Heracles Almelo | PSV Eindhoven | 0-2 | 2 - 4 points |
| 8/14/21 1:00 PM | 8/14/21 1:00 PM | Fortuna Sittard | FC Twente Enschede | 2-1 | 2 - 4 points |
| 8/14/21 2:00 PM | 8/14/21 2:00 PM | Ajax Amsterdam | NEC Nijmwegen | 5-0 | 2 - 4 points |
| 8/15/21 5:15 AM | 8/15/21 5:15 AM | Cambuur-Leeuwarden | FC Groningen | 1-2 | 2 - 4 points |
| 8/15/21 7:30 AM | 8/15/21 7:30 AM | FC Utrecht | Sparta Rotterdam | 4-0 | 2 - 4 points |
| 8/15/21 7:30 AM | 8/15/21 7:30 AM | PEC Zwolle | Vitesse Arnheim | 0-1 | 2 - 4 points |
| 8/15/21 9:45 AM | 8/15/21 9:45 AM | Willem II Tilburg | Feyenoord Rotterdam | 0-4 | 2 - 4 points |