Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 5/15/22 7:30 AM | 5/15/22 7:30 AM | FC Groningen | Cambuur-Leeuwarden | 2-3 | 2 - 4 points |
| 5/15/22 7:30 AM | 5/15/22 7:30 AM | NEC Nijmwegen | Fortuna Sittard | 0-1 | 2 - 4 points |
| 5/15/22 7:30 AM | 5/15/22 7:30 AM | SC Heerenveen | Go Ahead Eagles Deventer | 3-1 | 2 - 4 points |
| 5/15/22 7:30 AM | 5/15/22 7:30 AM | Feyenoord Rotterdam | FC Twente Enschede | 1-2 | 2 - 4 points |
| 5/15/22 7:30 AM | 5/15/22 7:30 AM | AZ Alkmaar | RKC Waalwijk | 1-3 | 2 - 4 points |
| 5/15/22 7:30 AM | 5/15/22 7:30 AM | Heracles Almelo | Sparta Rotterdam | 1-3 | 2 - 4 points |
| 5/15/22 7:30 AM | 5/15/22 7:30 AM | Vitesse Arnheim | Ajax Amsterdam | 2-2 | 2 - 4 points |
| 5/15/22 7:30 AM | 5/15/22 7:30 AM | PEC Zwolle | PSV Eindhoven | 1-2 | 2 - 4 points |
| 5/15/22 7:30 AM | 5/15/22 7:30 AM | Willem II Tilburg | FC Utrecht | 3-0 | 2 - 4 points |