Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 10/22/21 1:00 PM | 10/22/21 1:00 PM | Willem II Tilburg | Fortuna Sittard | 1-1 | 2 - 4 points |
| 10/23/21 11:45 AM | 10/23/21 11:45 AM | FC Utrecht | SC Heerenveen | 2-1 | 2 - 4 points |
| 10/23/21 1:00 PM | 10/23/21 1:00 PM | PEC Zwolle | Heracles Almelo | 1-0 | 2 - 4 points |
| 10/23/21 2:00 PM | 10/23/21 2:00 PM | RKC Waalwijk | Sparta Rotterdam | 1-0 | 2 - 4 points |
| 10/24/21 5:15 AM | 10/24/21 5:15 AM | FC Twente Enschede | NEC Nijmwegen | 1-2 | 2 - 4 points |
| 10/24/21 7:30 AM | 10/24/21 7:30 AM | Cambuur-Leeuwarden | Feyenoord Rotterdam | 2-3 | 2 - 4 points |
| 10/24/21 7:30 AM | 10/24/21 7:30 AM | Vitesse Arnheim | Go Ahead Eagles Deventer | 1-2 | 2 - 4 points |
| 10/24/21 9:45 AM | 10/24/21 9:45 AM | Ajax Amsterdam | PSV Eindhoven | 5-0 | 2 - 4 points |
| 10/24/21 1:00 PM | 10/24/21 1:00 PM | FC Groningen | AZ Alkmaar | 2-0 | 2 - 4 points |