Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 11/26/21 1:00 PM | 11/26/21 1:00 PM | NEC Nijmwegen | Cambuur-Leeuwarden | 2-3 | 2 - 4 points |
| 11/27/21 11:45 AM | 11/27/21 11:45 AM | Fortuna Sittard | FC Groningen | 1-4 | 2 - 4 points |
| 11/27/21 1:00 PM | 11/27/21 1:00 PM | PEC Zwolle | RKC Waalwijk | 0-0 | 2 - 4 points |
| 11/27/21 2:00 PM | 11/27/21 2:00 PM | Willem II Tilburg | Go Ahead Eagles Deventer | 0-1 | 2 - 4 points |
| 11/28/21 5:15 AM | 11/28/21 5:15 AM | Sparta Rotterdam | Ajax Amsterdam | 0-1 | 2 - 4 points |
| 11/28/21 7:30 AM | 11/28/21 7:30 AM | FC Twente Enschede | Feyenoord Rotterdam | 0-0 | 2 - 4 points |
| 11/28/21 7:30 AM | 11/28/21 7:30 AM | FC Utrecht | Heracles Almelo | 1-0 | 2 - 4 points |
| 11/28/21 9:45 AM | 11/28/21 9:45 AM | SC Heerenveen | PSV Eindhoven | 1-1 | 2 - 4 points |
| 11/28/21 1:00 PM | 11/28/21 1:00 PM | Vitesse Arnheim | AZ Alkmaar | 0-0 | 2 - 4 points |