Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 12/10/21 1:00 PM | 12/10/21 1:00 PM | Willem II Tilburg | Cambuur-Leeuwarden | 1-3 | 2 - 4 points |
| 12/11/21 11:45 AM | 12/11/21 11:45 AM | FC Utrecht | Go Ahead Eagles Deventer | 0-0 | 2 - 4 points |
| 12/11/21 1:00 PM | 12/11/21 1:00 PM | SC Heerenveen | Sparta Rotterdam | 0-0 | 2 - 4 points |
| 12/11/21 2:00 PM | 12/11/21 2:00 PM | PEC Zwolle | Fortuna Sittard | 0-1 | 2 - 4 points |
| 12/12/21 5:15 AM | 12/12/21 5:15 AM | FC Twente Enschede | RKC Waalwijk | 2-1 | 2 - 4 points |
| 12/12/21 7:30 AM | 12/12/21 7:30 AM | FC Groningen | Feyenoord Rotterdam | 1-1 | 2 - 4 points |
| 12/12/21 7:30 AM | 12/12/21 7:30 AM | Vitesse Arnheim | Heracles Almelo | 2-1 | 2 - 4 points |
| 12/12/21 9:45 AM | 12/12/21 9:45 AM | Ajax Amsterdam | AZ Alkmaar | 1-2 | 2 - 4 points |
| 12/12/21 1:00 PM | 12/12/21 1:00 PM | NEC Nijmwegen | PSV Eindhoven | 1-2 | 2 - 4 points |