Schedule
| Date | Dead line | Home | Away | Result | Points rule |
|---|---|---|---|---|---|
| 12/18/21 9:30 AM | 12/18/21 9:30 AM | Fortuna Sittard | FC Utrecht | 2-2 | 2 - 4 points |
| 12/18/21 11:45 AM | 12/18/21 11:45 AM | Sparta Rotterdam | Vitesse Arnheim | 2-2 | 2 - 4 points |
| 12/18/21 1:00 PM | 12/18/21 1:00 PM | Heracles Almelo | FC Groningen | 4-2 | 2 - 4 points |
| 12/18/21 1:00 PM | 12/18/21 1:00 PM | AZ Alkmaar | Willem II Tilburg | 4-1 | 2 - 4 points |
| 12/18/21 2:00 PM | 12/18/21 2:00 PM | PEC Zwolle | FC Twente Enschede | 1-3 | 2 - 4 points |
| 12/19/21 5:15 AM | 12/19/21 5:15 AM | Cambuur-Leeuwarden | SC Heerenveen | 1-2 | 2 - 4 points |
| 12/19/21 7:30 AM | 12/19/21 7:30 AM | Go Ahead Eagles Deventer | NEC Nijmwegen | 0-2 | 2 - 4 points |
| 12/19/21 7:30 AM | 12/19/21 7:30 AM | Feyenoord Rotterdam | Ajax Amsterdam | 0-2 | 2 - 4 points |
| 12/19/21 9:45 AM | 12/19/21 9:45 AM | RKC Waalwijk | PSV Eindhoven | 1-4 | 2 - 4 points |